Research

The mitochondria-targeted nanocapsules (MITO-Porter) in this study can pass through the cell and mitochondrial membranes to deliver target molecules inside the mitochondria. Conventional technologies using functional elements severely limit the size and type of molecules to be delivered, but the strategy using MITO-Porter, which encapsulates the target molecule, enables mitochondrial delivery independent of the molecular species.
When we prepared MITO-Porter with GFP (green) encapsulated and observed intracellular fluorescence microscopy, we observed many yellow signals that overlap with mitochondria (red), confirming efficient molecular delivery inside the mitochondria. We have also succeeded in introducing genes and nucleic acids into mitochondria, which had been impossible with existing nucleic acid delivery agents (targeting the nucleus and cytoplasm). We are also developing nanocapsules that can be adapted to living organisms.