phosphine ligand: 1
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Creation of Highly Active Catalysts Using Polystyrene-bridged Bisphosphine Ligands
Design of metal complex catalysts using polymeric carriers as the reaction site and development of an efficient synthetic processes
We have developed polystyrene-crosslinked bisphosphine ligands that can be used to create polymer-supported metal catalysts. Thanks to the effect of polymer topology, it is possible to suppress disproportionation of metal complexes and deactivation of catalysts caused by metal aggregation. It is particularly useful as a ligand for first transition series metal catalysts.
Research
Heterogeneous (insoluble) metal catalysts, which are easy to separate from the reaction mixture and have excellent reusability, can be used for organic synthesis in an environmentally-friendly manner. However, compared with the corresponding homogeneous (soluble) catalysts, they have a problem of reduced catalytic activity. We have developed a polystyrene-crosslinked bisphosphine ligand, PS-DPPBz, based on the topological control of polymer chains. Since this ligand is effective in generating highly active monochelate mononuclear transition metal complexes, it has significantly improved the efficiency of Ni-catalyzed reactions such as amination coupling of aryl chlorides and ester-azole coupling. PS-DPPBz can also be used for substrates to which it is difficult to apply existing catalysts. PS-DPPBz can be separated by filtration and reused, so it is expected to use this catalyst for industrial purposes.
Masaya Sawamura Professor
