Life Sciences
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Nanotechnology / Materials
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Environment
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1. No Poverty
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2. Zero Hunger
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3. Good Health and Well-being
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4. Quality Education
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5. Gender Equality
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6. Clean Water and Sanitation
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7. Affordable and Clean Energy
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8. Decent Work and Economic Growth
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9. Industry, Innovation and Infrastructure
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10. Reduced Inequality
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11. Sustainable Cities and Communities
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12. Responsible Consumption and Production
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13. Climate Action
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14. Life Below Water
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15. Life on Land
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16. Peace and Justice Strong Institutions
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17. Partnerships to achieve the Goal
3. Good Health and Well-being: 50
- 1. No Poverty
- 2. Zero Hunger
- 3. Good Health and Well-being
- 4. Quality Education
- 5. Gender Equality
- 6. Clean Water and Sanitation
- 7. Affordable and Clean Energy
- 8. Decent Work and Economic Growth
- 9. Industry, Innovation and Infrastructure
- 10. Reduced Inequality
- 11. Sustainable Cities and Communities
- 12. Responsible Consumption and Production
- 13. Climate Action
- 14. Life Below Water
- 15. Life on Land
- 16. Peace and Justice Strong Institutions
- 17. Partnerships to achieve the Goal
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Electrochemically Responsive Organic Dyes
From electrochromism to multiple responses (fluorescence, circularity)
Based on cationic organic dyes, which allow easy control of color tone, we offer a group of materials that can respond in multiple ways, including fluorescence and optical rotation (circular dichroism). This technology is designed to suppress the decomposition process of reduced species, and the bi-stability of oxidized and reduced species is such that exchange does not occur, even when they are mixed.
Research
Electrochromism is a general term for compounds that change their color tone in response to changes in external electrical potential. As materials that can undergo reversible color changes, they are attracting attention as light control materials for smart windows and display functions for electronic paper. Materials of which not only the color tone, but also fluorescence, optical rotation (circular dichroism), etc. can be changed, enable tailor-made responses according to the application.
With this technology, we provide a group of substances with multiple responses based on cationic organic dyes of which the color tone can easily be controlled. The reduced species of cationic dyes are generally reactive, and the repeatability of the response is low, but with this technology, the decomposition process of the reduced species is suppressed by incorporating two cationic moieties. The bi-stability of the oxidized and reduced species, in which no exchanges occur, even when they are mixed, makes it possible to apply this technology to high-density recording materials.Takanori Suzuki Professor -
Elucidation and Application of New Functions of Food by Evaluating the Intestinal Environment
Development of a new intestinal environment evaluation system for food and medicine
Food materials and ingredients, intestinal bacteria acting as parasites, and host Paneth cell α-defensins are the three elements that determine the “intestinal environment.” We are developing an intestinal environment evaluation system based on the new paradigm that crosstalk between these three elements affects health maintenance and disease to elucidate food functionality and apply it to disease prevention.
Research
In our original definition of “intestinal environment,” three elements, namely, food materials and ingredients, intestinal bacteria acting as parasites, and host Paneth cells α-defensin, determine the “intestinal environment,” and their crosstalk affects health maintenance and disease. This definition has prompted a paradigm shift in food functionality. The purpose of this study is to clarify the involvement of α-defensins in health maintenance, disease development and pathogenesis. This will help us establish a novel functional evaluation system of food and international criteria to evaluate the intestinal environment. By combining a tissue culture system with an α-defensin quantification system, we will lay the foundation for systematic analysis of the relationship between various intestinal functions and food functions of which the mechanisms are still unknown. This will be the first to elucidate immunostimulation and the control of aging substances by digested food materials and ingredients and drugs. We aim to obtain new scientific indicators to create high added value for food.
Kiminori Nakamura Associate Professor -
Elucidation of Nutrient Sensing Mechanisms in the Digestive Tract
Regulation of blood glucose by food peptides through their effects on the enteroendocrine system
Hormones secreted by endocrine cells that sense nutrients in the gastrointestinal tract regulate various physiological responses immediately after eating. In the course of studying this mechanism, we found through animal studies that food peptides can promote the secretion of the gastrointestinal hormone GLP-1 and reduce the elevation of plasma glucose levels.
Research
Various gastrointestinal hormones released by enteroendocrine cells that sense nutrients in the digestive tract, play an important role in regulating various physiological responses after meals. We have focused on the gastrointestinal hormone GLP-1, which is known as an anti-diabetic hormone, and found a food peptide (derived from corn) that strongly promotes the secretion of GLP-1. By orally administering this peptide to rats, we found that GLP-1 secretion was promoted and plasma glucose elevation was suppressed. Our research is aimed to elucidate how this peptide is recognized by enteroendocrine cells, and to control postprandial plasma glucose levels and appetite by controlling the secretion of gastrointestinal hormones with various food components.
Tohru Hira Associate Professor -
From Landscape to Hometown Revitalization
Creating community value through resident participation
From the perspective of landscape planning, we are researching ways to preserve and utilize the local environment by linking it to people's awareness and social understanding. In recent years, we have been practically researching how values and spatial needs that change with society, such as “health” and “funerals” can be reflected in the landscape.
Research
To conserve and manage local resources through resident participation, the “landscape” approach, which views the region from people's perspective, is very effective. We are developing research on people's and society's landscape perception, and conducting empirical research on how to utilize people’s place attachment in local resource management.
Environmental planning using health resorts (Kurort)
In Germany, medical insurance covers services at government-recognized recuperation and health resorts that make use of the natural environment such as hot springs, the sea, and the climate. In Japan, too, efforts are underway to create health resorts (Kurort) that combine health tourism with local health promotion.
Forest utilization as burial sites:
To utilize forest resources, we are conducting practical research on the development of forest burial sites in Japan, modeled after Germany’s examples. As a new method of managing forests, which account for 70% of Japan’s land area, we are promoting the creation of forest burial sites in various regions as a means of regional management in aging society.Hirofumi Ueda Associate Professor -
Functional Modification of Food Proteins
Sugar modification for processing and improved health functions
Using the Maillard reaction to bind sugars to fish meat proteins, we can prepare water-soluble muscle proteins and peptides with modified processing properties and health functions (anti-inflammatory and antioxidant function, suppression of blood pressure increase and suppression of lipid absorption, etc.). It can also be applied to livestock and poultry meat and various proteins.
Research
Summary
The Maillard reaction can be used to bind reducing sugars to proteins and peptides to create new fish food products with modified properties.
Comparison with conventional technology and uniqueness
High-molecular complex proteins such as muscle proteins are prone to thermal aggregation, and progression of the Maillard reaction leads to deterioration of various properties. We have developed a new method to create functional materials from unstable proteins such as fish food proteins by controlling both protein denaturation and the Maillard reaction.
Characteristics of the materials and manufacturing technologies that can be created.
1. Introduction of sugar chains without using chemical reagents
2. Making muscle soluble in water and adding highly emulsifiable properties
3. Improving the stability of unstable proteins
4. Modification of in vivo active health functions
5. Can be applied to the development of functional peptides.
6. No limitations on the form of the raw materialsHiroki Saeki Professor -
Functional Regulators and Biomarkers of Immune and Cancer Cells
Using low-molecular-weight nucleic acid (microRNA) to control the function of immune and cancer cells, and to determine the immune status of subjects.
We provide microRNAs that control the immune response of the body and the proliferation of cancer cells. It is expected to be used as a nucleic acid medicine to improve the immune status and to treat cancer patients, and as a new biomarker to determine the immune condition of subjects by monitoring microRNA in the serum.
Research
In recent years, cancer immunotherapy has made remarkable progress, and immune checkpoint inhibitors have been marketed as drugs. On the other hand, biomarkers to determine the immune status of subjects are needed to improve the clinical efficacy of cancer treatment and to provide safe and secure treatment with fewer side effects.
In this study, we discovered novel microRNAs that can regulate the immune responses or cancer cell proliferation. These microRNAs show promise as nucleic acid drugs that can be administered directly to the body to improve the immune status, or as drugs that can be added to immune cells processed or prepared from the body to regulate their functions.
It is also possible to determine the immune status of cancer patients by monitoring the level of microRNA in the serum, and it is expected to use this as a useful biomarker to evaluate the anti-tumor immune response to cancer immunotherapy and predict side effects caused by abnormal enhancement of the immune system, and to select treatment methods.Hidemitsu Kitamura Associate Professor -
Gel that is Stronger Than Steel
Soft and tough composite material
By conjugating glass fiber and self-healing gel, we have achieved a gel that is stronger than carbon fiber-reinforced plastic (CFRP). Since the base material is a gel, it is as flexible as rubber against bending, but tougher than CFRP against tearing, making it difficult to break.
Research
The glass fiber composite gel we have developed exhibits unbreakable, untearable and tear-resistant properties. Generally speaking, CFRP and glass fiber reinforced plastic (GFRP) are widely used as composite materials. Similar to these fiber-reinforced plastics, fiber-reinforced gels are hard and resistant to tension because of the characteristics of the fibers, while being soft and flexible on bending because of the characteristics of the gel. The self-healing polyampholyte (PA) gel used as the base material is also strong as such thanks to its ability to dissipate a large amount of energy against deformation. Since the gel is flexible, when it is combined with fiber, local distortions can be transmitted through the fiber to the distant base material, resulting in large energy dissipation of the entire material, meaning that it is remarkably strong.
Takayuki Kurokawa ProfessorPh. D -
Gesture Recognition System Using Ultrasound
A system that can recognize gestures, including the internal state of the human body, based on the response to ultrasonic waves propagated in the human body.
We are developing a method of recognizing gestures, including the internal condition of the human body, such as the amount of force applied to an object, by transmitting ultrasonic waves to the human body using microphones and speakers in smartwatches or other devices and analyzing the responses.
Research
Our gesture recognition system uses a method called active acoustic sensing, which sends out sound waves and analyzes the state of the object using the returned response. This method enables gesture recognition including the internal condition of the human body, such as the amount of force applied, which has been difficult to recognize with conventional accelerometers. It is intended to use this method in a wearable computing environment, and it is unique in that it can simultaneously acquire both externally visible gestures and internal gestures using microphones and speakers that are installed in many devices. For example, we envision that our method can be applied to gesture operations when both hands are occupied in a wearable environment, and to the lifelog of the amount of force applied under stress or other situations.
Hiroki Watanabe Assistant Professor -
High Strength Gel That Spontaneously Bonds Strongly with Bone Tissue
Development of a safe, high-strength bonding method between wet materials and bone, which has been difficult to achieve so far, by utilizing bone healing in living organisms
In answer to the issue of in vivo fixation by applying the much anticipated high-strength hydrogel as a next-generation artificial cartilage or cartilage tissue regeneration scaffold material, we have developed a simple, non-toxic, high-strength adhesion method using hydroxyapatite, an inorganic component of bone tissue.
Research
The high-strength, high-toughness double-network gel (DN gel) previously developed by our group has excellent properties such as low wear on cartilage and induction of cartilage tissue regeneration in a natural joint, and is being studied for application as an artificial cartilage material and cartilage regeneration induction material. On the other hand, it is difficult to fix and maintain such a gel in a natural joint, which has been a major issue with the practical use of this material. In this study, we developed a fixation method that allows bone tissue regeneration to progress spontaneously into the gel and adhere firmly by compounding hydroxyapatite (HAp), the main inorganic component of bone tissue, to the surface layer of the DN gel. In addition to excellent mechanical properties and cartilage regeneration ability, the realization of non-toxic in vivo adhesion to bone is a great step forward toward the practical application of DN gel for joint treatment.
Takayuki Nonoyama Associate Professor -
Hyperpolarized 13C MRI for Genetic Mutation Imaging
Non-invasive visualization of genetic mutations in tumors by metabolic MRI
The outcome of cancer treatment largely depends on the type of genetic mutation that the cancer cells carry. Using the characteristic metabolic changes brought about by genetic mutations as an indicator, we are developing a molecular imaging technique to identify mutated genes non-invasively using the latest metabolic MRI.
Research
Hyperpolarized 13C nuclear magnetic resonance imaging (MRI) is a state-of-the-art technique for real-time visualization of metabolic reactions in vivo by temporarily amplifying the MRI signal of any compound labeled with 13C tens of thousands of times. It is expected to be a dream molecular imaging technology that can acquire signals from deep inside the body, which is difficult with optical imaging without radiation exposure like PET/CT.
Cells become cancerous through the accumulation of genetic mutations, and the type of mutation greatly influences the response to cancer therapy. Many cancer-causing mutations are associated with characteristic metabolic changes. Hyperpolarized 13C MRI can be used to non-invasively identify mutated genes in tumors by looking at specific metabolic changes.Shingo Matsumoto Associate Professor -
In Vivo Nucleic Acid Delivery System Based on the Development of Unique Functional Lipids
Balancing world-class functional delivery of nucleic acids and safety
We have developed a unique group of functional lipids for the safe and efficient in vivo delivery of siRNA. The lipid nanoparticles containing these lipids showed world-class functional delivery of siRNA in hepatocytes due to their excellent endosomal escape ability and high safety due to their biodegradability.
Research
The key to the practical application of siRNA is the development of superior delivery technology, but there is still much room for improvement in the delivery efficiency. In addition, from the viewpoint of practicality, it is also important to secure a wide safe therapeutic window. It is also highly desirable to develop platform technologies that can provide appropriate formulations for different purposes without being limited to specific applications. To achieve these goals, we have developed a unique group of pH-sensitive cationic lipids. We achieved the modulation of acid dissociation constants, which is an important factor for the pharmacokinetics of lipid nanoparticles, enabling a target-specific molecular design. The lipid nanoparticles containing the novel lipid CL4H6 induced gene silencing in hepatocytes with world-class efficiency. No significant hepatotoxicity was also observed even after the administration of approximately 3,000-fold higher dose for 50% gene silencing, thus a high level of safety was confirmed. CL4H6 was rapidly degraded and eliminated after siRNA delivery.
Yusuke Sato Assistant Professor -
Liposomal Bioluminescence Immunoassay
Preparation of liposomes encapsulating luciferase and application as an ultra-sensitive label in immunoassays
We have encapsulated the enzyme luciferase (Luc), which catalyzes bioluminescence reactions, in liposome, a lipid bilayer vesicle, and applied it as an ultrasensitive label for immunoassays. As a model substance, we performed immunoassay of C-reactive protein, a marker of inflammation, and found that it could be quantified.
Research
Since immunoassay is an essential technology in clinical laboratories and for environmental analysis, technological advances (simplification, high sensitivity, high throughput, etc.) has come essential as the analytes are becoming more diverse and smaller. We aim to construct an ultra-sensitive immunoassay system in which the bioluminescent enzyme Luc is encapsulated in lipid bilayer membrane vesicles, called liposomes, and use it as a label in immunoassays. By encapsulating a large number of Luc in liposomes, it becomes possible to label antibodies in a stable state. However, although the method of encapsulating enzymes inside liposomes is already known, no studies have been done on Luc. In our study, we have encapsulated heat-stabilized recombinant Luc into liposomes and evaluated the amount and stability of the encapsulation. We have also constructed an immunoassay system for C-reactive protein using Luc-encapsulated liposomes as a label.
Hirofumi Tani Associate Professor -
MALDI Matrix for Sensitive and High-Resolution Structural Analysis of Unmodified Sialylated Glycans and Glycoconjugates
We have developed a matrix that can ionize sialylated glycans and glycoconjugates without modifying the carboxylic acid moiety of the sialic acids, and can analyze them with high sensitivity and resolution (reflector mode) without desorption of the sialic acid residue.
Research
Sialylation (addition of sialic acid) of glycans and glycoconjugates is an important biomarker involved in various biological phenomena such as development, differentiation, disease, infection, and immunity. MALDI (matrix-assisted laser desorption/ionization) is a simple and sensitive soft ionization method. However, the ionization efficiency of unmodified sialic acid-containing glycans is low, and there is a problem that the spectrum becomes complicated due to cleavage of sialic acids or other reasons. With this technique, we succeeded in measuring sialylated glycans and glycoconjugates with high sensitivity and high resolution without undergoing any modification process by improving the addition system to the conventional matrix while suppressing sialic acid desorption. With the change in the cleavage pattern and the increased sensitivity, TOF/TOF analysis and pseudo-MS3 analysis can now be performed using ultra-trace samples. This method does not require chemical modification and separation steps, and enables reaction tracking and rapid sample analysis.
Hiroshi Hinou Professor ProfessorPh.D. -
Micro-/nano-patterns Created with Biomaterials
Bio-based micro-/nano-patterns that mimic biological structures for application to cell culture tools and tissue regeneration
Using biomaterials such as collagen and dental materials, we are producing micro-/nano-patterns that mimic biological structures. Depending on the shape of the pattern and the type of material, it can lead to the improvement of cell functions. While pursuing new possibilities, we aim to apply our technology to cell culture tools and periodontal tissue regeneration.
Research
In this study, we are using nanoimprinting to pattern typical biomaterials. We hope that the designed micro-/nano-scale shapes can be used to control cell functions and contribute to the development of novel cell culture tools and tissue regeneration.
● Comparison with conventional technology: It is characterized by unprecedented production of regular biomaterial patterns, and is expected to contribute to the discovery of new functions. (*Conventionally, irregular, flat or industrial plastics)
● Effectiveness: Patterning greatly improves the number of cells attached and the degree of elongation compared to flat surfaces. It also makes it easy to align cells in grooves. This can lead to the 3D construction of extracellular matrix (ECM).
● Future vision: We aim to regenerate tissues with a similar structure as that of living organisms by developing patterned materials not only in a flat plane but also in 2.5 and 3 dimensions through further layering.Tsukasa Akasaka Associate Professor -
Mitochondria-targeted Nanocapsules (MITO-Porter)
Technology to introduce drugs, proteins and nucleic acids into mitochondria
The mitochondrion is attracting attention as an organelle that contributes to the treatment of diseases, maintenance of beauty and health and the development of the life sciences. We have successfully developed a mitochondria-targeted nanocapsule (MITO-Porter) and are aiming to commercialize this nanocapsule.
Research
The mitochondria-targeted nanocapsules (MITO-Porter) in this study can pass through the cell and mitochondrial membranes to deliver target molecules inside the mitochondria. Conventional technologies using functional elements severely limit the size and type of molecules to be delivered, but the strategy using MITO-Porter, which encapsulates the target molecule, enables mitochondrial delivery independent of the molecular species.
When we prepared MITO-Porter with GFP (green) encapsulated and observed intracellular fluorescence microscopy, we observed many yellow signals that overlap with mitochondria (red), confirming efficient molecular delivery inside the mitochondria. We have also succeeded in introducing genes and nucleic acids into mitochondria, which had been impossible with existing nucleic acid delivery agents (targeting the nucleus and cytoplasm). We are also developing nanocapsules that can be adapted to living organisms.Yuma Yamada Professor -
Multimedia Artificial Intelligence Technology Reaching Social Implementation
Approaching the practical application of AI technology through industry-university collaborative research!
With this research, we are developing artificial intelligence technology for multimedia data, mainly images, video, music, and audio. We are handling data related to medical images, social infrastructure data, materials science and other fields, mainly through industry-university collaborative research.
Research
We are not only conducting the world's most advanced artificial intelligence research, but also promoting research in interdisciplinary areas and taking on the challenge of solving real-world problems. Specifically, in medical imaging research, we have collaborated with many medical institutions in Japan to build AI technology that surpasses human diagnostic accuracy. In medical and civil engineering research, we have built Explainable AI (XAI), which not only enables learning of small amounts of data, a challenge in AI research, but also enables explanations of judgment results, making the technology usable in the real world. In recent years, we have also developed human-centric AI technology that can make decisions like humans by introducing information strongly related to human interests, such as human brain activity and eye gaze data, into the AI learning process.
Takahiro Ogawa Professor -
Open Advanced Research Facilities Initiative (Project for Creation of Research Platforms and Sharing of Advanced Research Infrastructure)
Microscopic imaging platform for atoms and molecules
Promotion and expansion of the isotope microscope system installed at the Equipment Management Center for shared use by industry, academia and government.
Research
We invite, select and implement proposals for the effective use of stable isotope imaging technology, which is a special feature of the isotope microscope system, to expand it to industrial innovation.
Upon hearing the word, “isotopes,” the concept of “age measurement” immediately comes to mind. Actually, until now, isotope microscopes have been used to analyze isotope ratios, primarily in minerals and other areas of space science. This is a result obtained by observing the as-is cross-section of the obtained sample. However, by changing the concept of the measurement method, we can expand the use of isotope microscopes to industrial application. In other words, by actively doping a target sample with an isotope element, rather than observing it “as such,” it becomes possible to measure the desired imaging we were unable to see before. The use of stable rather than radioactive isotopes also allows us to work safely.Hisayoshi Yurimoto Professor -
Open Advanced Research Facilities Initiative NMR Shared Platform
Program for promotion of shared use of advanced NMR facilities
The Advanced NMR Facility is the largest NMR facility in Hokkaido, and is not only open to local industries, but also to industry, academia and research institutes nationwide.
Research
The Faculty of Advanced Life Science and the Faculty of Science of Hokkaido University play the central role in managing the Advanced NMR Facility. In cooperation with the Institute for the Promotion of Business-Regional Collaboration and the Global Facility Center of the Creative Research Institution, we aim to promote new applications, primarily in industry. For more information on the specifications of the 800 MHz solution NMR, 600 MHz solid-state NMR and other instruments, as well as application procedures for their use, please see our website. We hope that you will take advantage of the project to promote shared use of the Advanced NMR Facility at Hokkaido University.
Makoto Demura Professor -
Peptide and Glycopeptide Cyclization Technology
Significant improvement of peptide cyclization efficiency by controlling hydrogen bonds
By focusing on forming a hydrogen-bond network in the solvent, we have succeeded in both efficient peptide cyclization and improved solubility of poorly soluble peptides. This system can apply to drug discovery and molecular tool design.
Research
Cyclic peptides are an ideal molecular form for exploring biologically active compounds (drug discovery) and the design of molecular tools in life science. Cyclization of the peptide backbone can control their conformational stability, orientation, and symmetry. However, peptide cyclization requires specific dilution conditions and complex basic protection strategies. We found that combining a hydrogen-bond-controlled solvent system and a base-free condensation agent system enables the efficient cyclization of poorly soluble peptides under highly concentrated conditions. The simplicity of this technology gives a wide range of applications for drug discovery and life sciences by facilitating the free design and mass production of cyclic peptides.
Hiroshi Hinou Professor ProfessorPh.D. -
Portable Liquid Chromatograph
Battery-powered, ultra-light, ultra-compact chemical analyzer
Using proprietary technology, we have miniaturized the pump, column and detector, all key components of liquid chromatography, realizing a compact, B5 size, lightweight and portable liquid chromatograph weighing 2 kg. This allows us to instantly obtain analysis results on the spot.
Research
The pump we have developed for liquid chromatography is based on electroosmotic phenomena and can operate for a long time on dry batteries. Since there is no mechanical drive, it is extremely compact and lightweight, and does not generate pulsating flow. Using microfabrication technology, the column and (electrochemical and UV) detectors are mounted on small amounts of substrate, the size of a business card. Conventional packing materials are used for the column, so the same analysis conditions as before can be applied directly without modification. The electrochemical detector uses a uniquely developed comb-shaped electrode. Although small in size, it has comparable sensitivity as conventional detectors. Liquid chromatographs currently used as the main instrument for chemical analysis are large and heavy, limiting their use to specific locations in the laboratory, but the instrument we have developed can easily be used anywhere. The amount of solvent used can also be reduced to 1/100 to 1/1000 of conventional detectors.
Akihiko Ishida Assistant ProfessorDoctor of Engineering
