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Synthesis of Fluorinated Aromatic Carboxylic Acids
Using electricity to make useful carboxylic acids from carbon dioxide
We have succeeded in regioselectively synthesizing a variety of fluorine-containing aromatic carboxylic acids, which are promising as new fluorine-containing building blocks, from readily available aromatic compounds containing several fluorine atoms and carbon dioxide, and achieved good yields by organic electrolysis.
Content of research
The introduction of fluorine atoms into organic compounds is very important in the fields of medicine, agrochemicals, and functional materials. There is a method of synthesizing fluorine-containing organic compounds by using fluorine-containing building blocks, but such compounds are still expensive and limited in quantity, and there is a high need for research and development. In this study, we succeeded in synthesizing fluorine-containing aromatic carboxylic acids with various functional groups from readily available fluorine-containing aromatic compounds and carbon dioxide, and achieved good yields using the organic electrolysis method. The fluorine-containing aromatic carboxylic acids synthesized in this study include a variety of new compounds that are difficult to synthesize by conventional methods, and are expected to be used as promising new fluorine-containing building blocks for the synthesis of pharmaceuticals, agrochemicals, and highly functional materials.
Potential for social implementation
- ・New fluorine-containing building blocks
- ・Synthetic raw materials for new biologically active compounds, including pharmaceuticals and agrochemicals
- ・Synthetic raw materials for new high functional materials, including functional polymers and organic EL
- ・Carbon dioxide fixation technology
Appealing points to industry and local governments
In this study, we have succeeded in synthesizing several new fluorine-containing building blocks that were difficult to synthesize by conventional methods. Currently, we continue to develop the synthesis of new fluorine-containing building blocks of aromatic carboxylic acids by the same research. We would like to hear from you if you have any fluorine-containing building blocks that have potential industrial applications.