Content of research

Age-related macular degeneration and diabetic retinopathy are retinal and choroidal disorders that major causes of blindness and are regarded as chronic inflammatory disorders associated with lifestyle-related diseases. However, we have yet to develop a fundamental treatment or elucidate the pathogenesis of these disorders. We have previously reported that the receptor-associated prorenin system (RAPS) regulates the molecular pathogenesis of disorders upstream of inflammation and angiogenesis in organ damage in lifestyle-related diseases. We are currently conducting basic research targeting the (pro)renin receptor, which is at the center of the receptor-associated prorenin system, with a view to drug discovery using technologies such as comprehensive small molecule compound screening and drug molecular design methods. Using animal models of diseases, we are also attempting to elucidate the function of (pro)renin receptors and to establish therapeutic strategies for early intervention in disease states while minimizing the impact on the physiological functions.

Potential for social implementation

• ・Drugs for retinal choroidal disorders (diabetic retinopathy, age-related macular degeneration, etc.)
• ・Diabetic complication drugs
• ・Inflammatory disease drugs
• ・Cancer inhibitors

Appealing points to industry and local governments

We are developing functional inhibitors targeting RAPS using techniques such as structural analysis, nucleic acid organic chemistry, and pharmaceutical molecular design methods, and are conducting basic research with a view to multiple drug discovery.