Hokkaido University Research Profiles

Nanotechnology / Materials

Creation of Highly Active Catalysts Using Polystyrene-bridged Bisphosphine Ligands

Design of metal complex catalysts using polymeric carriers as the reaction site and development of an efficient synthetic processes

We have developed polystyrene-crosslinked bisphosphine ligands that can be used to create polymer-supported metal catalysts. Thanks to the effect of polymer topology, it is possible to suppress disproportionation of metal complexes and deactivation of catalysts caused by metal aggregation. It is particularly useful as a ligand for first transition series metal catalysts.

Content of research

Heterogeneous (insoluble) metal catalysts, which are easy to separate from the reaction mixture and have excellent reusability, can be used for organic synthesis in an environmentally-friendly manner. However, compared with the corresponding homogeneous (soluble) catalysts, they have a problem of reduced catalytic activity. We have developed a polystyrene-crosslinked bisphosphine ligand, PS-DPPBz, based on the topological control of polymer chains. Since this ligand is effective in generating highly active monochelate mononuclear transition metal complexes, it has significantly improved the efficiency of Ni-catalyzed reactions such as amination coupling of aryl chlorides and ester-azole coupling. PS-DPPBz can also be used for substrates to which it is difficult to apply existing catalysts. PS-DPPBz can be separated by filtration and reused, so it is expected to use this catalyst for industrial purposes.

Potential for social implementation

  • ・Improving the efficiency of the manufacturing processes
  • ・Synthesis of novel molecules
  • ・Development of new materials and new drugs

Appealing points to industry and local governments

Based on our original catalyst design, we are working to improve the efficiency of the synthesis process and develop new molecular transformation methods. Polystyrene-crosslinked bisphosphine-metal catalysis is a highly practical technology in terms of preparation cost and process efficiency.

Intellectual property related to this research

特願2017-505406 「高分子遷移金属錯体、その製造方法及びその利用」