Development of a Method to Prevent Post-Thoracic Surgery Atrial Fibrillation Using Carnitine
We will conduct a randomized, multicenter study to determine whether perioperative oral carnitine therapy can reduce postoperative atrial fibrillation (POAF) in patients with valvular heart disease. In case of lung and esophageal cancer patients, a single-arm interventional study will be conducted because similar studies have not been conducted before.
Content of research
Postoperative atrial fibrillation (POAF) after thoracic surgery is a frequent problem leading to increased incidences of stroke, heart failure, and infection, and resulting in prolonged hospitalization. Although beta-blockers are the only effective treatment, their efficacy rate is less than 50%, and their side effects often preclude their use. Recently, carnitine preparations, which are fatty acid metabolism ameliorators, have been reported to suppress arrhythmias after myocardial infarction and coronary artery bypass surgery due to their anti-inflammatory and fatty acid metabolism ameliorating effects. As part of this project, we will conduct a randomized, multicenter study to determine whether perioperative carnitine medication can suppress POAF in patients with valvular heart disease. In case of lung cancer and esophageal cancer patients, a single-arm interventional study will be conducted to evaluate the safety and POAF reduction rate, which will be useful for future randomized studies.
Potential for social implementation
- Development of a method to prevent post-thoracic surgery atrial fibrillation
Appealing points to industry and local governments
In terms of drugs and nutrition that improve fatty acid metabolism, this could lead to the discovery of inexpensive, safe, and effective ways to prevent complications.