Hokkaido University Research Profiles

Life Sciences

Technology to Create Unique Glycan Derivative Libraries × Microarray Analysis System That Can Be Used Anywhere

Original library using automated glycan synthesis technology × Microarray technology supporting on-site medical care and research

Glycan-related interactions are important targets of infectious diseases and cancer diagnosis. We have developed a microarray system that can be used anywhere to utilize the libraries of glycans, glycoconjugates, glycan-related inhibitors, and their derivatives that have been constructed and accumulated in the process of developing automated glycan synthesis technology.

Content of research

Microarray technology is a technology that enables simultaneous comparative analysis of the interaction between a large number of compound libraries with well-defined structures and sequences and sample components. We also have the most advanced technology to design and produce our own carbohydrate compound libraries as molecules for microarray analysis based on our automated carbohydrate synthesis technology. The interaction information possessed by carbohydrates is widely used as biomarkers for in vitro diagnostics, such as blood types, serotypes such as O157, and cancer diagnostic markers (CAxx). In addition, we have succeeded in developing an independently powered mobile analyzer that can be used for online diagnosis, such as analysis of infection patterns associated with mutations in infectious diseases and detailed analysis of vaccine effects, by performing specimen collection and microarray analysis on the spot using a smartphone as a terminal.

  • A leap forward from automated glycan synthesis technology

  • The future of microarrays that can be used anywhere

Potential for social implementation

  • This technology can be used for fieldwork monitoring of zoonotic diseases, vaccine evaluation, diagnosis in the examination room and at home, search for biological resources, the post-corona era, the super-aging society era, infectious disease countermeasures that meet SDGs, tracking of health indicators, and the search for biological resources.

Appealing points to industry and local governments

We would like to prioritize the dissemination of microarray analysis technology that can be used everywhere, while focusing on our original contents to compete with other technologies. We welcome both joint research with partners who agree with our priority on dissemination and focus on the uniqueness of the presented contents. We also welcome the development of applications other than microarrays that utilize our original molecular surface presentation technology.